Key role of local acetaldehyde in upper GI tract carcinogenesis
نویسندگان
چکیده
منابع مشابه
Local Acetaldehyde—An Essential Role in Alcohol-Related Upper Gastrointestinal Tract Carcinogenesis
The resident microbiome plays a key role in exposure of the upper gastrointestinal (GI) tract mucosa to acetaldehyde (ACH), a carcinogenic metabolite of ethanol. Poor oral health is a significant risk factor for oral and esophageal carcinogenesis and is characterized by a dysbiotic microbiome. Dysbiosis leads to increased growth of opportunistic pathogens (such as Candida yeasts) and may cause ...
متن کاملLocal Acetaldehyde Production as a Pathogenetic Factor for Upper Digestive Tract Cancers in Humans
........................................................................................................................ 8
متن کاملHuman Papillomavirus and Carcinogenesis in the Upper Aero-Digestive Tract
The evaluation of causality for these infectious agents as human carcinogens is difficult given their ubiquitous nature, the substantial length of time between infection and the cancer event, the nature of cofactors, and the rarity of malignancy among those infected. Thus, a central problem for the epidemiologist is to define the natural history of infection and to identify those factors that a...
متن کاملRetinoid chemoprevention studies in upper aerodigestive tract and lung carcinogenesis.
Chemoprevention is a clinical strategy to block or reverse carcinogenesis before the development of invasive cancer. Studies of chemoprevention in the lungs and upper aerodigestive tract have relied on the field carcinogenesis hypothesis, which predicts that diffuse epithelial injury will result from exposure of that epithelium to carcinogens. This hypothesis is supported by the frequent occurr...
متن کاملACUPUNCTURE AND GI TRACT DISORDERS About GI tract disorders
Around 2–4 in 1,000 people in Northern Europe have ulcerative colitis or Crohn’s disease (Rubin 2000). Both are chronic, relapsing, inflammatory disorders of the gastrointestinal tract with several shared clinical features, but with largely distinct risk factors, genetic, immunological, anatomical and histological features, and response to therapy (DTB 2003). Their treatment, which includes med...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Best Practice & Research Clinical Gastroenterology
سال: 2017
ISSN: 1521-6918
DOI: 10.1016/j.bpg.2017.09.016